학술논문
The NCBI Comparative Genome Viewer (CGV) is an interactive visualization tool for the analysis of whole-genome eukaryotic alignments.
Document Type
article
Author
Sanjida H Rangwala; Dmitry V Rudnev; Victor V Ananiev; Dong-Ha Oh; Andrea Asztalos; Barrett Benica; Evgeny A Borodin; Nathan Bouk; Vladislav I Evgeniev; Vamsi K Kodali; Vadim Lotov; Eyal Mozes; Marina V Omelchenko; Sofya Savkina; Ekaterina Sukharnikov; Joël Virothaisakun; Terence D Murphy; Kim D Pruitt; Valerie A Schneider
Source
PLoS Biology, Vol 22, Iss 5, p e3002405 (2024)
Subject
Language
English
ISSN
1544-9173
1545-7885
1545-7885
Abstract
We report a new visualization tool for analysis of whole-genome assembly-assembly alignments, the Comparative Genome Viewer (CGV) (https://ncbi.nlm.nih.gov/genome/cgv/). CGV visualizes pairwise same-species and cross-species alignments provided by National Center for Biotechnology Information (NCBI) using assembly alignment algorithms developed by us and others. Researchers can examine large structural differences spanning chromosomes, such as inversions or translocations. Users can also navigate to regions of interest, where they can detect and analyze smaller-scale deletions and rearrangements within specific chromosome or gene regions. RefSeq or user-provided gene annotation is displayed where available. CGV currently provides approximately 800 alignments from over 350 animal, plant, and fungal species. CGV and related NCBI viewers are undergoing active development to further meet needs of the research community in comparative genome visualization.