학술논문
Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease
Document Type
article
Author
Hong Yuen Wong; Quanhu Sheng; Amanda B. Hesterberg; Sarah Croessmann; Brenda L. Rios; Khem Giri; Jorgen Jackson; Adam X. Miranda; Evan Watkins; Kerry R. Schaffer; Meredith Donahue; Elizabeth Winkler; David F. Penson; Joseph A. Smith; S. Duke Herrell; Amy N. Luckenbaugh; Daniel A. Barocas; Young J. Kim; Diana Graves; Giovanna A. Giannico; Jeffrey C. Rathmell; Ben H. Park; Jennifer B. Gordetsky; Paula J. Hurley
Source
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The molecular and cellular underpinnings of cribriform prostate cancer aggressiveness remain to be explored. Here, the authors perform single-cell RNA-sequencing, TCR sequencing and histology and reveal cancer cell intrinsic pathways and an immunosuppressive tumour microenvironment.