학술논문
Improvement of patients reported outcomes and neurocognitive performances after Direct-Acting Antivirals: a longitudinal study
Document Type
article
Author
Source
Infectious Diseases and Tropical Medicine, Vol 7 (2021)
Subject
Language
English
ISSN
2379-4054
Abstract
BACKGROUND: HCV chronic infection may affect Patient-Reported Outcomes (PROs) and HCV related neuroinflammation might correlate with neurocognitive performances (NCP) dysfunction. PATIENTS AND METHODS: A prospective observational study on HCV infected patients treated with direct-acting antivirals (DAA) was conducted at the University Department of Infectious and Tropical Diseases of Brescia, ASST Spedali Civili General Hospital (Italy) from October 2017 to June 2018. Data were collected at baseline (BL), end of treatment (EOT) and 12 weeks after EOT (FU12W). PROs were evaluated with Chronic Liver Disease Questionnaire (CLDQ), Fatigue Severity Scale (FSS), Visual Analogue Fatigue Scale (VAFS) and Work Productivity and Activity Impairment Questionnaire: General Health (WPAI:GH). Montreal Cognitive Assessment (MoCA) test evaluated NCP. Exclusion criteria were: HIV infection with CD4+ nadir