학술논문
Spatially interacting phosphorylation sites and mutations in cancer
Document Type
article
Author
Kuan-lin Huang; Adam D. Scott; Daniel Cui Zhou; Liang-Bo Wang; Amila Weerasinghe; Abdulkadir Elmas; Ruiyang Liu; Yige Wu; Michael C. Wendl; Matthew A. Wyczalkowski; Jessika Baral; Sohini Sengupta; Chin-Wen Lai; Kelly Ruggles; Samuel H. Payne; Benjamin Raphael; David Fenyö; Ken Chen; Gordon Mills; Li Ding
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associated with activating mutation and genetic dependencies in cancer.