학술논문
The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance between protein folding and degradation.