학술논문
Spontaneous-timed versus controlled noninvasive ventilation in chronic hypercapnia – a crossover trial
Document Type
article
Source
Medical Devices: Evidence and Research, Vol Volume 12, Pp 173-181 (2019)
Subject
Language
English
ISSN
1179-1470
Abstract
Jens Kerl, Ekkehard Höhn, Dieter Köhler, Dominic DellwegDepartment for Pulmonary Medicine, Intensive Care Medicine and Sleep Medicine, Fachkrankenhaus Kloster Grafschaft GmbH, Schmallenberg, 57392, GermanyBackground: There is an ongoing debate about optimal ventilator modes and settings during noninvasive ventilation (NIV).Objectives: To compare the effect of spontaneous-timed (ST) and controlled NIV on carbon dioxide reduction in patients suffering from chronic hypercapnia.Methods: Night and daytime blood gas analysis, lung function tests and 6 minute walking distance tests (6MWD) were done before and after every 6-week treatment.Results: This randomized prospective crossover trial included 42 patients. Pooled data analysis showed a decrease of nocturnal CO2 from 54.8±5.9 mmHg to 41.6±5.5 mmHg during ST ventilation (p