학술논문
Caspase-11 promotes allergic airway inflammation
Document Type
article
Author
Zbigniew Zasłona; Ewelina Flis; Mieszko M. Wilk; Richard G. Carroll; Eva M. Palsson-McDermott; Mark M. Hughes; Ciana Diskin; Kathy Banahan; Dylan G. Ryan; Alexander Hooftman; Alicja Misiak; Jay Kearney; Gunter Lochnit; Wilhelm Bertrams; Timm Greulich; Bernd Schmeck; Oliver J. McElvaney; Kingston H. G. Mills; Ed C. Lavelle; Małgorzata Wygrecka; Emma M. Creagh; Luke A. J. O’Neill
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, and that mice lacking caspase-11 are strongly protected from allergic airway inflammation.