학술논문
Bone health in autosomal dominant polycystic kidney disease (ADPKD) patients after kidney transplantation
Document Type
article
Author
Dalia Zubidat; Christian Hanna; Amarjyot K. Randhawa; Byron H. Smith; Maroun Chedid; Daniel-Hasan N. Kaidbay; Luca Nardelli; Yaman G. Mkhaimer; Reem M. Neal; Charles D. Madsen; Sarah R. Senum; Adriana V. Gregory; Timothy L. Kline; Ziad M. Zoghby; Stephen M. Broski; Naim S. Issa; Peter C. Harris; Vicente E. Torres; Jad G. Sfeir; Fouad T. Chebib
Source
Bone Reports, Vol 18, Iss , Pp 101655- (2023)
Subject
Language
English
ISSN
2352-1872
Abstract
ADPKD is caused by pathogenic variants in PKD1 or PKD2, encoding polycystin-1 and -2 proteins. Polycystins are expressed in osteoblasts and chondrocytes in animal models, and loss of function is associated with low bone mineral density (BMD) and volume. However, it is unclear whether these variants impact bone strength in ADPKD patients. Here, we examined BMD in ADPKD after kidney transplantation (KTx). This retrospective observational study retrieved data from adult patients who received a KTx over the past 15 years. Patients with available dual-energy X-ray absorptiometry (DXA) of the hip and/or lumbar spine (LS) post-transplant were included. ADPKD patients (n = 340) were matched 1:1 by age (±2 years) at KTx and sex with non-diabetic non-ADPKD patients (n = 340). Patients with ADPKD had slightly higher BMD and T-scores at the right total hip (TH) as compared to non-ADPKD patients [BMD: 0.951 vs. 0.897, p