학술논문
Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
Document Type
article
Author
Kristopher J. Schmit; Pierre Garcia; Alessia Sciortino; Velma T.E. Aho; Beatriz Pardo Rodriguez; Mélanie H. Thomas; Jean-Jacques Gérardy; Irati Bastero Acha; Rashi Halder; Camille Cialini; Tony Heurtaux; Irina Ostahi; Susheel B. Busi; Léa Grandmougin; Tuesday Lowndes; Yogesh Singh; Eric C. Martens; Michel Mittelbronn; Manuel Buttini; Paul Wilmes
Source
Cell Reports, Vol 42, Iss 9, Pp 113071- (2023)
Subject
Language
English
ISSN
2211-1247
Abstract
Summary: Parkinson’s disease (PD) is a neurological disorder characterized by motor dysfunction, dopaminergic neuron loss, and alpha-synuclein (αSyn) inclusions. Many PD risk factors are known, but those affecting disease progression are not. Lifestyle and microbial dysbiosis are candidates in this context. Diet-driven gut dysbiosis and reduced barrier function may increase exposure of enteric neurons to toxins. Here, we study whether fiber deprivation and exposure to bacterial curli, a protein cross-seeding with αSyn, individually or together, exacerbate disease in the enteric and central nervous systems of a transgenic PD mouse model. We analyze the gut microbiome, motor behavior, and gastrointestinal and brain pathologies. We find that diet and bacterial curli alter the microbiome and exacerbate motor performance, as well as intestinal and brain pathologies, but to different extents. Our results shed important insights on how diet and microbiome-borne insults modulate PD progression via the gut-brain axis and have implications for lifestyle management of PD.