부산대학교 도서관

Mélissa Santorini,1 Thomas Ferreira De Moura,1 Sara Barraud,2 Claude Fabien Litré,3 Catherine Brugniart,1 Alexandre Denoyer,1 Zoubir Djerada,4 Carl Arndt1 1Department of Ophthalmology, Robert Debré Hospital, Reims, France; 2Department of Endocrinology, Robert Debré Hospital, Reims, France; 3Department of Neurosurgery, Robert Debré Hospital, Reims, France; 4Department of Pharmacology, Robert Debré Hospital, Reims, FranceCorrespondence: Mélissa Santorini, Department of Ophthalmology, Robert Debré Hospital, Reims, France, Tel +33616521403, Email santorini.melissa@gmail.comPurpose: To evaluate the relationship between different macular thickness parameters analyzed by SD-OCT and the central visual field (VF) evaluated with automated kinetic perimetry in a cohort of patients with pituitary tumors.Methods: Data from patients with pituitary adenoma treated at Reims University Hospital between October 1st, 2017, and May 31st, 2018 were collected. All patients underwent an automated kinetic perimetry and a SD-OCT to map the ganglion cell complex (GCC), the ganglion cell layer (GCL) thickness and the retinal nerve fiber layer (RNFL) using devices from two different manufacturers. Univariate and multivariate analysis were used to evaluate the correlation between the area of central VF in square degrees (deg2) and the SD-OCT parameters (μm).Results: Eighty-eight eyes were included in the analysis. All the thickness parameters measured in SD-OCT decreased with the visual field alteration. The best correlation was observed between superior thickness parameters (GCC, GCL) and the inferior central visual field. The most pertinent predictive factors for visual field loss were the inferior central GCL and the nasal RNFL (both AUC=0.775) with a sensitivity respectively of 86% and 70%.Conclusion: This study suggests that both GCC, GCL thickness parameters could be reliable predictors of central visual field impairment in patients with pituitary tumors. There was no significative difference between both devices.Keywords: optic chiasma, visual field, ganglion cell complex, ganglion cell layers, compressive optic neuropathy, optic coherence tomography, retinal nerve fiber layer, pituitary tumors, pituitary adenomas