학술논문
Application of Biomarkers in Obese Infertile Women: A Genetic Tool for a Personalized Treatment
Document Type
article
Author
Charalampos Voros; Kyriakos Bananis; Angeliki Papapanagiotou; Abraham Pouliakis; Konstantina Mavriki; Ioannis Gkaniatsos; Maria Anastasia Daskalaki; Ioannis Prokopakis; Charalampos Tsimpoukelis; Aristotelis-Marios Koulakmanidis; Menelaos Darlas; Sofia Anysiadou; Georgios Daskalakis; Ekaterini Domali
Source
Journal of Clinical Medicine, Vol 13, Iss 8, p 2261 (2024)
Subject
Language
English
ISSN
2077-0383
Abstract
This study investigates links between CART and leptin gene expression, FSH receptor Asn680Ser polymorphism, and reproductive hormones in morbidly obese patients under 40 years old, facing infertility, and undergoing bariatric surgery. A total of 29 women were included in this study. A hormonal profile along with detection of CART and leptin gene expression was evaluated before and after bariatric surgery. Additionally, the presence or absence of Asn680Ser of the FSHR gene was studied. Following bariatric surgery, a mean reduction in BMI (16.03 kg/m2) was observed in all women. FSH levels preoperatively varied significantly among genotypes, with medians of 8.1, 9.5, and 10.3 for individuals without polymorphism, heterozygotes, and homozygotes, respectively (p = 0.0408). Post surgery, marginal differences in FSH levels were observed (5.8, 7.1, and 8.2, respectively) (p = 0.0356). E2 and LH levels exhibited no significant genotype-based differences pre and post surgery. Presurgical E2 levels were 29.6, 29.8, and 29.6, respectively (p = 0.91634), while postsurgical levels were 51.2, 47.8, and 47 (p = 0.7720). LH levels followed similar patterns. Our findings highlight bariatric surgery’s positive impact on BMI reduction and its potential connection to genetic markers, hormones, and infertility. This suggests personalized treatments and offers a valuable genetic tool for better fertility outcomes in obese individuals.