학술논문
INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial
Document Type
article
Author
Lili Song; Chen Chen; Xiaoying Chen; Yijia Guo; Feifeng Liu; Yapeng Lin; Laurent Billot; Qiang Li; Hueiming Liu; Lei Si; Menglu Ouyang; Hisatomi Arima; Philip M. Bath; Gary A. Ford; Thompson Robinson; Else Charlotte Sandset; Jeffrey L. Saver; Nikola Sprigg; H. Bart van der Worp; Chunfang Zhang; Jie Yang; Gang Li; Craig S. Anderson; for the INTERACT4 investigators
Source
Trials, Vol 22, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
1745-6215
Abstract
Abstract Background Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment and risk of intracranial hemorrhage in ischemic stroke (IS). We present the design of the fourth INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4). Methods A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed trial of pre-hospital BP lowering in 3116 hypertensive patients with suspected acute stroke at 50+ sites in China. Patients are randomized through a mobile phone digital system to intensive BP lowering to a target systolic BP of