학술논문
DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study
Document Type
article
Author
Source
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-13 (2024)
Subject
Language
English
ISSN
1868-7083
Abstract
Abstract Background Metabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an epigenome-wide approach, we aimed to investigate DNA methylation changes occurring secondary to psychotropic treatment and evaluate associations between 1-month metabolic changes and both baseline and 1-month changes in DNA methylation levels. Seventy-nine patients starting a weight gain inducing psychotropic treatment were selected from the PsyMetab study cohort. Epigenome-wide DNA methylation was measured at baseline and after 1 month of treatment, using the Illumina Methylation EPIC BeadChip. Results A global methylation increase was noted after the first month of treatment, which was more pronounced (p