학술논문
Successful treatment of acquired amegakaryocytic thrombocytopenia with eltrombopag and immunosuppressant
Document Type
article
Author
Source
Platelets, Vol 33, Iss 6, Pp 951-953 (2022)
Subject
Language
English
ISSN
0953-7104
1369-1635
09537104
1369-1635
09537104
Abstract
Acquired amegakaryocytic thrombocypenia (AAMT) is an extremely rare hematologic disorder and standard treatment strategy has not been established. We described herein two cases of AAMT who were fully responded to eltrombopag and immunosuppressant. Patient 1 was refractory to steroid, IVIG and recombinant human thrombopoietin (rhTPO). Patient 2 did not respond to high dosage of steroid, IVIG, rhTPO and rituximab. Moreover, his AAMT progressed to aplastic anemia in 5 months. Both patients took eltrombopag and immunosuppressant, then they achieved long-term remission without obvious side effects. Our findings suggest that this combination can be a valuable alternative in AAMT.