학술논문

Titanium nanosheet as robust and biosafe drug carrier for combined photochemo cancer therapy
Document Type
article
Source
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-15 (2022)
Subject
Titanium nanosheet
Polydopamine modification
Chemo-photothermal therapy
Drug delivery
Biotechnology
TP248.13-248.65
Medical technology
R855-855.5
Language
English
ISSN
1477-3155
Abstract
Abstract Two-dimensional (2D) Titanium nanosheets (Ti NSs) have shown many excellent properties, such as nontoxicity, satisfactory photothermal conversion efficacy, etc. However, the biomedical applications of Ti NSs have not been intensively investigated. Herein, we synthesized a multifunctional Ti NS drug delivery system modified with polydopamine/polyethylene glycol (Ti@PDA-PEG) and applied simultaneously for photothermal therapy and chemotherapy. Doxorubicin (DOX) was utilized as a model drug. Ti@PDA-PEG NS shows an ultrahigh antitumor drug DOX loading (Ti@PDA-PEG-DOX). The prepared Ti@PDA-PEG-DOX NS as robust drug delivery system demonstrates great stability and excellent multi-response drug-release capabilities, including pH-responsive and near-infrared -responsive behavior and obviously high photothermal efficiency. Both in vitro and in vivo experimental results have shown high biosafety and outstanding antitumor effects. Therefore, this work exhibits the enormous potential of a multifunctional platform in the treatment of tumors and may stimulate interest in the exploration of other new 2D nanomaterials for biomedical applications. Graphical Abstract