학술논문
Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions
Document Type
article
Author
Source
Communications Chemistry, Vol 5, Iss 1, Pp 1-10 (2022)
Subject
Language
English
ISSN
2399-3669
Abstract
Alanine substitution in peptides is crucial for studying peptide-based inhibitors of protein–protein interactions, but limited information is obtained from single alanine substitution. Here, the authors develop a label-free combinatorial alanine affinity selection platform to establish multi-alanine mutational tolerance and provide structure-activity relationships.