학술논문
Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children
Document Type
article
Author
Oumar Attaher; Bruce Swihart; Lauren Dang; Gaoussou Santara; Almahamoudou Mahamar; Sekouba Keita; Adama Dembele; Bacary Soumana Diarra; Djibrilla Issiaka; Amadou Barry; Youssoufa Sidibé; Yahia T. Dicko; Seydou Traore; Fanta Koita; Ouelematou Ndiaye; Alassane Dicko; Jonathan D. Kurtis; Patrick E. Duffy; Michal Fried
Source
International Journal of Infectious Diseases, Vol 139, Iss , Pp 171-175 (2024)
Subject
Language
English
ISSN
1201-9712
Abstract
Objectives: The association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies described the protective role of platelets in directly killing Plasmodium parasites, mediated by platelet factor 4 (PF4) binding to Duffy antigen. This study aimed to evaluate the protective role of platelets in young children who are Duffy antigen-negative, such as those in sub-Saharan Africa. Methods: A zero-inflated negative binomial model was used to relate platelet count and parasite density data collected in a longitudinal birth cohort. Platelet factors were measured by enzyme-linked immunosorbent assay in samples collected from malaria-infected children who participated in a cross-sectional study. Results: We described that an increase of 10,000 platelets/μl was associated with a 2.76% reduction in parasite count. Increasing levels of PF4 and CXCL7 levels were also significantly associated with a reduction in parasite count. Conclusions: Platelets play a protective role in reducing parasite burden in Duffy-negative children, possibly mediated through activation of the innate immune system.