학술논문
Efficacy and safety of first-line or second-line selective laser trabeculoplasty for normal-tension glaucoma: a multicentre cohort study
Document Type
article
Author
Tomoko Naito; Kazuyuki Hirooka; Toru Nakazawa; Masaki Tanito; Shiro Mizoue; Katsuyoshi Suzuki; Keiji Yoshikawa; Itaru Kimura; Yasushi Ikuno; Takako Miki; Kazuhisa Sugiyama; Tairo Kimura; Akiko Narita; Tadashi Nakano; Tomoyuki Watanabe; Koji Nitta; Kae Sugihara; Maki Katai; Takuji Matsuda; Hiroaki Ozaki; Kaori Komatsu; Yoshiaki Saito; Takeshi Sagara; Aika Tsutsui; Akiko Ishida; Satoru Tsuda; Toyoaki Tsumura; Naoki Tojo; Naoto Tokuda; Kenji Nakamoto; Naka Shiratori; Mami Nanno; Naoya Nezu; Yoshitaka Tasaka; Shigeru Mori; Shigeki Yamabayashi; Kimihito Konno; Miyuki Domoto
Source
BMJ Open Ophthalmology, Vol 9, Iss 1 (2024)
Subject
Language
English
ISSN
2397-3269
Abstract
Background/aims This study aimed to investigate and compare the efficacy and safety of first-line and second-line selective laser trabeculoplasty (SLT) in Japanese patients with normal-tension glaucoma (NTG).Methods 100 patients with NTG were enrolled in this study. Patients were treated with SLT as a first-line or second-line treatment for NTG. Main outcome measures were intraocular pressure (IOP) reduction rate, outflow pressure improvement rate (ΔOP), success rate at 1 year and complications. Success was defined as ΔOP≥20% (criterion A) or an IOP reduction ≥20% (criterion B) without additional IOP-lowering eye-drops, repeat SLT or additional glaucoma surgeries. The incidence of transient IOP spike (>5 mm Hg from the pretreatment IOP), conjunctival hyperaemia, inflammation in the anterior chamber and visual impairment due to SLT were assessed.Results A total of 99 patients (99 eyes) were initially enrolled in this study, including 74 eyes assigned to the first-line SLT group and 25 eyes to the second-line SLT group. The mean IOP of 16.3±2.1 mm Hg before SLT decreased by 17.1%±9.5% to 13.4±1.9 mm Hg at 12 months after SLT in the first-line group (p