학술논문
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
Document Type
article
Author
Heng-Huan Lee; Ying-Nai Wang; Wen-Hao Yang; Weiya Xia; Yongkun Wei; Li-Chuan Chan; Yu-Han Wang; Zhou Jiang; Shouping Xu; Jun Yao; Yufan Qiu; Yi-Hsin Hsu; Wei-Lun Hwang; Meisi Yan; Jong-Ho Cha; Jennifer L. Hsu; Jia Shen; Yuanqing Ye; Xifeng Wu; Ming-Feng Hou; Lin-Ming Tseng; Shao-Chun Wang; Mei-Ren Pan; Chin-Hua Yang; Yuan-Liang Wang; Hirohito Yamaguchi; Da Pang; Gabriel N. Hortobagyi; Dihua Yu; Mien-Chie Hung
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.