학술논문
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Document Type
article
Author
Marco Matejcic; Edward J. Saunders; Tokhir Dadaev; Mark N. Brook; Kan Wang; Xin Sheng; Ali Amin Al Olama; Fredrick R. Schumacher; Sue A. Ingles; Koveela Govindasami; Sara Benlloch; Sonja I. Berndt; Demetrius Albanes; Stella Koutros; Kenneth Muir; Victoria L. Stevens; Susan M. Gapstur; Catherine M. Tangen; Jyotsna Batra; Judith Clements; Henrik Gronberg; Nora Pashayan; Johanna Schleutker; Alicja Wolk; Catharine West; Lorelei Mucci; Peter Kraft; Géraldine Cancel-Tassin; Karina D. Sorensen; Lovise Maehle; Eli M. Grindedal; Sara S. Strom; David E. Neal; Freddie C. Hamdy; Jenny L. Donovan; Ruth C. Travis; Robert J. Hamilton; Barry Rosenstein; Yong-Jie Lu; Graham G. Giles; Adam S. Kibel; Ana Vega; Jeanette T. Bensen; Manolis Kogevinas; Kathryn L. Penney; Jong Y. Park; Janet L. Stanford; Cezary Cybulski; Børge G. Nordestgaard; Hermann Brenner; Christiane Maier; Jeri Kim; Manuel R. Teixeira; Susan L. Neuhausen; Kim De Ruyck; Azad Razack; Lisa F. Newcomb; Davor Lessel; Radka Kaneva; Nawaid Usmani; Frank Claessens; Paul A. Townsend; Manuela Gago-Dominguez; Monique J. Roobol; Florence Menegaux; Kay-Tee Khaw; Lisa A. Cannon-Albright; Hardev Pandha; Stephen N. Thibodeau; Daniel J. Schaid; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Fredrik Wiklund; Stephen J. Chanock; Douglas F. Easton; Rosalind A. Eeles; Zsofia Kote-Jarai; David V. Conti; Christopher A. Haiman
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.