학술논문
A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike
Document Type
article
Author
Mathieu Claireaux; Tom G. Caniels; Marlon de Gast; Julianna Han; Denise Guerra; Gius Kerster; Barbera D. C. van Schaik; Aldo Jongejan; Angela I. Schriek; Marloes Grobben; Philip J. M. Brouwer; Karlijn van der Straten; Yoann Aldon; Joan Capella-Pujol; Jonne L. Snitselaar; Wouter Olijhoek; Aafke Aartse; Mitch Brinkkemper; Ilja Bontjer; Judith A. Burger; Meliawati Poniman; Tom P. L. Bijl; Jonathan L. Torres; Jeffrey Copps; Isabel Cuella Martin; Steven W. de Taeye; Godelieve J. de Bree; Andrew B. Ward; Kwinten Sliepen; Antoine H. C. van Kampen; Perry D. Moerland; Rogier W. Sanders; Marit J. van Gils
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell repertoire, authors identify following infection, a subset of B cells enriched and almost exclusively target a non-neutralizing S2 epitope present in aberrant forms.