학술논문
Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
Document Type
article
Author
Source
Molecules, Vol 16, Iss 3, Pp 2519-2526 (2011)
Subject
Language
English
ISSN
16032519
1420-3049
1420-3049
Abstract
Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.