학술논문
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
Document Type
article
Author
Rahul Nahar; Weiwei Zhai; Tong Zhang; Angela Takano; Alexis J. Khng; Yin Yeng Lee; Xingliang Liu; Chong Hee Lim; Tina P. T. Koh; Zaw Win Aung; Tony Kiat Hon Lim; Lavanya Veeravalli; Ju Yuan; Audrey S. M. Teo; Cheryl X. Chan; Huay Mei Poh; Ivan M. L. Chua; Audrey Ann Liew; Dawn Ping Xi Lau; Xue Lin Kwang; Chee Keong Toh; Wan-Teck Lim; Bing Lim; Wai Leong Tam; Eng-Huat Tan; Axel M. Hillmer; Daniel S. W. Tan
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance.