학술논문
Neotropical Sylvatic Mosquitoes and Aedes aegypti Are Not Competent to Transmit 17DD Attenuated Yellow Fever Virus from Vaccinated Viremic New World Non-Human Primates
Document Type
article
Author
Rafaella Moraes de Miranda; Rosilainy Surubi Fernandes; André Tavares da Silva-Fernandes; Anielly Ferreira-de-Brito; Silvia Bahadian Moreira; Renata Carvalho Pereira; Ygara da Silva Mendes; Sheila Maria Barbosa de Lima; Alcides Pissinatti; Marcos da Silva Freire; Jerônimo Augusto Fonseca Alencar; Ricardo Lourenco-de-Oliveira
Source
Viruses, Vol 14, Iss 10, p 2231 (2022)
Subject
Language
English
ISSN
1999-4915
Abstract
Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haemagogus janthinomys/capricornii, Sabethes albiprivus, and Sabethes identicus, as well as the urban vector Aedes aegypti for YF 17DD attenuated vaccine virus when fed directly on eleven viremic lion tamarins or artificially challenged with the same virus. No infection was detected in 689 mosquitoes engorged on viremic lion tamarins whose viremia ranged from 1.05 × 103 to 6.61 × 103 FFU/mL, nor in those artificially taking ≤ 1 × 103 PFU/mL. Low viremia presented by YF 17DD-vaccinated New World NHPs combined with the low capacity and null dissemination ability in sylvatic and domestic mosquitoes of this attenuated virus suggest no risk of its transmission in nature. Thus, vaccination of captive and free-living NHPs against YFV is a safe public health strategy.