학술논문
Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
Document Type
article
Author
Emily Adland; Jane Millar; Nomonde Bengu; Maximilian Muenchhoff; Rowena Fillis; Kenneth Sprenger; Vuyokasi Ntlantsana; Julia Roider; Vinicius Vieira; Katya Govender; John Adamson; Nelisiwe Nxele; Christina Ochsenbauer; John Kappes; Luisa Mori; Jeroen van Lobenstein; Yeney Graza; Kogielambal Chinniah; Constant Kapongo; Roopesh Bhoola; Malini Krishna; Philippa C. Matthews; Ruth Penya Poderos; Marta Colomer Lluch; Maria C. Puertas; Julia G. Prado; Neil McKerrow; Moherndran Archary; Thumbi Ndung’u; Andreas Groll; Pieter Jooste; Javier Martinez-Picado; Marcus Altfeld; Philip Goulder
Source
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Sex differences in the immune response to vaccines and infections have been well described in children and adults. Here the authors describe, in a cohort of 177 HIV-infected infants, innate immune sex differences in fetal life that increase female susceptibility to intrauterine HIV infection and increase the chances of subsequent HIV remission in infected males.