학술논문
Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate
Document Type
article
Author
Kwinten Sliepen; Laura Radić; Joan Capella-Pujol; Yasunori Watanabe; Ian Zon; Ana Chumbe; Wen-Hsin Lee; Marlon de Gast; Jelle Koopsen; Sylvie Koekkoek; Iván del Moral-Sánchez; Philip J. M. Brouwer; Rashmi Ravichandran; Gabriel Ozorowski; Neil P. King; Andrew B. Ward; Marit J. van Gils; Max Crispin; Janke Schinkel; Rogier W. Sanders
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
E1E2 spike on the hepatitis C virion is an important target for vaccine design. Here, the authors permute the subunits to generate E2E1 immunogens and show that mosaic nanoparticles displaying different E2E1 antigens elicit cross-neutralizing antibodies in rabbits.