학술논문
The rise and fall of the ancient northern pike master sex-determining gene
Document Type
article
Author
Qiaowei Pan; Romain Feron; Elodie Jouanno; Hugo Darras; Amaury Herpin; Ben Koop; Eric Rondeau; Frederick W Goetz; Wesley A Larson; Louis Bernatchez; Mike Tringali; Stephen S Curran; Eric Saillant; Gael PJ Denys; Frank A von Hippel; Songlin Chen; J Andrés López; Hugo Verreycken; Konrad Ocalewicz; Rene Guyomard; Camille Eche; Jerome Lluch; Celine Roques; Hongxia Hu; Roger Tabor; Patrick DeHaan; Krista M Nichols; Laurent Journot; Hugues Parrinello; Christophe Klopp; Elena A Interesova; Vladimir Trifonov; Manfred Schartl; John Postlethwait; Yann Guiguen
Source
eLife, Vol 10 (2021)
Subject
Language
English
ISSN
2050-084X
Abstract
The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species- or population-specific sex determination transitions, including a recent loss of a Y chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.