학술논문
Oral mycobiota and pancreatic ductal adenocarcinoma
Document Type
article
Author
Source
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
1471-2407
Abstract
Abstract Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for survival. Preliminary research demonstrated significant associations between structural alternation of mycobiota and PDAC. In this study, we investigated the associations between oral mycobiota and PDAC. We further explored mycobiota biomarkers for PDAC detection. We enrolled 34 PDAC patients and 35 matched healthy controls from West China hospital in Southwest China. Demographic data, clinical information, and salivary samples were collected. Mycobiota characteristics were defined using Internal Transcribed Spacer (ITS) ribosomal RNA sequencing. We found that the PDAC patients had significant increase in fungal abundance (P