학술논문
Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss
Document Type
article
Author
Source
Brazilian Journal of Medical and Biological Research, Vol 51, Iss 3 (2018)
Subject
Language
English
ISSN
1414-431X
1414-431x
1414-431x
Abstract
Occupational noise-induced hearing loss (ONIHL) is a prevalent occupational disorder that impairs auditory function in workers exposed to prolonged noise. However, serum microRNA expression in ONIHL subjects has not yet been studied. We aimed to compare the serum microRNA expression profiles in male workers of ONIHL subjects and controls. MicroRNA microarray analysis revealed that four serum microRNAs were differentially expressed between controls (n=3) and ONIHL subjects (n=3). Among these microRNAs, three were upregulated (hsa-miR-3162-5p, hsa-miR-4484, hsa-miR-1229-5p) and one was downregulated (hsa-miR-4652-3p) in the ONIHL group (fold change >1.5 and Pbon value