학술논문
Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases
Document Type
article
Author
Luuk Wieske; Laura Y. L. Kummer; Koos P. J. van Dam; Eileen W. Stalman; Anneke J. van der Kooi; Joost Raaphorst; Mark Löwenberg; R. Bart Takkenberg; Adriaan G. Volkers; Geert R. A. M. D’Haens; Sander W. Tas; Phyllis I. Spuls; Marcel W. Bekkenk; Annelie H. Musters; Nicoline F. Post; Angela L. Bosma; Marc L. Hilhorst; Yosta Vegting; Frederike J. Bemelman; Joep Killestein; Zoé L. E. van Kempen; Alexandre E. Voskuyl; Bo Broens; Agner Parra Sanchez; Gertjan Wolbink; Laura Boekel; Abraham Rutgers; Karina de Leeuw; Barbara Horváth; Jan J. G. M. Verschuuren; Annabel M. Ruiter; Lotte van Ouwerkerk; Diane van der Woude; Cornelia F. Allaart; Y. K. Onno Teng; Pieter van Paassen; Matthias H. Busch; B. Papay Jallah; Esther Brusse; Pieter A. van Doorn; Adája E. Baars; Dirkjan Hijnen; Corine R. G. Schreurs; W. Ludo van der Pol; H. Stephan Goedee; Maurice Steenhuis; Theo Rispens; Anja ten Brinke; Niels J. M. Verstegen; Koos A. H. Zwinderman; S. Marieke van Ham; Taco W. Kuijpers; Filip Eftimov; on behalf of the T2B! immunity against SARS-CoV-2 study group
Source
BMC Medicine, Vol 20, Iss 1, Pp 1-6 (2022)
Subject
Language
English
ISSN
1741-7015
Abstract
Abstract Background Studies have suggested incremental short-term adverse events (AE) after repeated vaccination. In this report, we assessed occurrence and risk factors for short-term AEs following repeated SARS-CoV-2 vaccination in patients with various immune-mediated inflammatory diseases (IMIDs). Methods Self-reported daily questionnaires on AEs during the first 7 days after vaccination were obtained of 2259 individuals (2081 patients and 178 controls) participating in an ongoing prospective multicenter cohort study on SARS-CoV-2 vaccination in patients with various IMIDs in the Netherlands (T2B-COVID). Relative risks were calculated for potential risk factors associated with clinically relevant AE (rAE), defined as AE lasting longer than 2 days or impacting daily life. Results In total, 5454 vaccinations were recorded (1737 first, 1992 second and 1478 third vaccinations). Multiple sclerosis, Crohn’s disease and rheumatoid arthritis were the largest disease groups. rAEs were reported by 57.3% (95% CI 54.8–59.8) of patients after the first vaccination, 61.5% (95% CI 59.2–63.7) after the second vaccination and 58% (95% CI 55.3–60.6) after the third vaccination. At day 7 after the first, second and third vaccination, respectively, 7.6% (95% CI 6.3–9.1), 7.4% (95% CI 6.2–8.7) and 6.8% (95% CI 5.4–8.3) of patients still reported AEs impacting daily life. Hospital admissions and allergic reactions were uncommon (