학술논문
COVID-19 convalescent plasma boosts early antibody titer and does not influence the adaptive immune response
Document Type
article
Author
John F. McDyer; Mahzad Azimpouran; Valerie L. Durkalski-Mauldin; Robert G. Clevenger; Sharon D. Yeatts; Xutao Deng; William Barsan; Robert Silbergleit; Nahed El Kassar; Iulia Popescu; Dimiter Dimitrov; Wei Li; Emily J. Lyons; Sophia C. Lieber; Mars Stone; Frederick K. Korley; Clifton W. Callaway; Larry J. Dumont; Philip J. Norris; for the SIREN-C3PO Investigators
Source
JCI Insight, Vol 8, Iss 8 (2023)
Subject
Language
English
ISSN
2379-3708
Abstract
Multiple randomized, controlled clinical trials have yielded discordant results regarding the efficacy of convalescent plasma in outpatients, with some showing an approximately 2-fold reduction in risk and others showing no effect. We quantified binding and neutralizing antibody levels in 492 of the 511 participants from the Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO) of a single unit of COVID-19 convalescent plasma (CCP) versus saline infusion. In a subset of 70 participants, peripheral blood mononuclear cells were obtained to define the evolution of B and T cell responses through day 30. Binding and neutralizing antibody responses were approximately 2-fold higher 1 hour after infusion in recipients of CCP compared with saline plus multivitamin, but levels achieved by the native immune system by day 15 were almost 10-fold higher than those seen immediately after CCP administration. Infusion of CCP did not block generation of the host antibody response or skew B or T cell phenotype or maturation. Activated CD4+ and CD8+ T cells were associated with more severe disease outcome. These data show that CCP leads to a measurable boost in anti–SARS-CoV-2 antibodies but that the boost is modest and may not be sufficient to alter disease course.