학술논문
Research progress on relationship between N6-adenylate methylation modification and cell transformation and associated mechanism
Document Type
article
Author
Source
环境与职业医学, Vol 40, Iss 5, Pp 601-608 (2023)
Subject
Language
English
Chinese
Chinese
ISSN
2095-9982
Abstract
As a reversible and dynamic epigenetic marker, N6-adenylate methylation (m6A) modification is the most common mRNA modification in eukaryotes. This paper briefly described how m6A can influence RNA splicing, stability, and translation after transcription, and then participate in a variety of signaling pathways and biological and pathological processes, regulating cell proliferation, apoptosis, epithelial mesenchymal transformation (EMT) processes, and tumor invasion and metastasis. In addition, according to current studies, m6A methyltransferases (writers) are believed to promote EMT and tumor development, and readers and erasers both promote and inhibit EMT in different research objects. In this review, we summarized the mechanism of m6A modification and its role in cell transformation, and pointed out the direction of disease treatment.