학술논문
Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium
Document Type
article
Author
Ruyi Huang; Yongyue Wei; Rayjean J. Hung; Geoffrey Liu; Li Su; Ruyang Zhang; Xuchen Zong; Zuo-Feng Zhang; Hal Morgenstern; Irene Brüske; Joachim Heinrich; Yun-Chul Hong; Jin Hee Kim; Michele Cote; Angela Wenzlaff; Ann G. Schwartz; Isabelle Stucker; John Mclaughlin; Michael W. Marcus; Michael P.A. Davies; Triantafillos Liloglou; John K. Field; Keitaro Matsuo; Matt Barnett; Mark Thornquist; Gary Goodman; Yi Wang; Size Chen; Ping Yang; Eric J. Duell; Angeline S. Andrew; Philip Lazarus; Joshua Muscat; Penella Woll; Janet Horsman; M. Dawn Teare; Anath Flugelman; Gad Rennert; Yan Zhang; Hermann Brenner; Christa Stegmaier; Erik H.F.M. van der Heijden; Katja Aben; Lambertus Kiemeney; Juan Barros-Dios; Monica Pérez-Ríos; Alberto Ruano-Ravina; Neil E. Caporaso; Pier Alberto Bertazzi; Maria Teresa Landi; Juncheng Dai; Hongbing Shen; Guillermo Fernandez-Tardon; Marta Rodriguez-Suarez; Adonina Tardon; David C. Christiani
Source
EBioMedicine, Vol 2, Iss 11, Pp 1677-1685 (2015)
Subject
Language
English
ISSN
2352-3964
Abstract
Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose–response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5–9 years to 89%quit_for_≥20 years declined SCLC risk vs. subjects who had quit smoking