학술논문
Ultra-large chemical libraries for the discovery of high-affinity peptide binders
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 106 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 108 members.