학술논문
Hyperglycaemia in pregnancy and offspring blood pressure: a systematic review and meta-analysis
Document Type
article
Author
Source
Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-16 (2023)
Subject
Language
English
ISSN
1758-5996
Abstract
Abstract Background Hyperglycemia in pregnancy (HIP) is suggested to be a risk factor for elevated blood pressure (BP) in offspring. However, the empirical evidence was mixed. Thus, this systematic review and meta-analysis was conducted to synthesize current evidence assessing the association between HIP and BP in offspring. Methods We searched PubMed, MEDLINE, and Embase to identify articles published from inception until 9 February 2021. A random-effects meta-analysis was performed to calculate a pooled effect size and 95% confidence interval (CI). Furthermore, the effects were evaluated separately while grouping by the offspring’s sex, region, economic level, published year, insulin treatment status, and BP measurement. Each article was independently reviewed for quality. Results Of 3385 citations identified, 23 studies involving 88695 offspring were included. The study found that the offspring of women with HIP had an increased level of both systolic blood pressure (SBP; mean difference 1.90, 95% CI 1.09 to 2.70 mmHg, P