학술논문
The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
Document Type
article
Author
Xinyi Yang; Yuqi Zhu; Jingna Xun; Jun Liu; Qing Wen; Yixiao Lin; Xiaoting Shen; Jun Chen; Songhua Yuan; Xiaying Zhao; Jing Wang; Hanyu Pan; Jinlong Yang; Zhiming Liang; Yue Liang; Qinru Lin; Huitong Liang; Chunyan Zhou; Li Jin; Weijian Xie; Jianping Liu; Daru Lu; Tianlei Ying; Yinzhong Shen; Xiaoyan Zhang; Jianqing Xu; Chunhua Yin; Pengfei Wang; Shibo Jiang; Hongzhou Lu; Huanzhang Zhu
Source
iScience, Vol 25, Iss 9, Pp 105016- (2022)
Subject
Language
English
ISSN
2589-0042
Abstract
Summary: The SARS-CoV-2 variants B.1.617.1 (Kappa) contain multiple mutations in the spike protein. However, the effect of B.1.617.1 lineage-related mutants on viral infectivity and inactivated-virus vaccine efficacy remains to be defined. We therefore constructed 12 B.1.617.1-related pseudoviruses and systematically studied the effects of mutations on virus infectivity and neutralization resistance to convalescent and inactivated virus vaccine sera. Our results show that the B.1.617.1 variant exhibited both higher infectivity and neutralization resistance in sera at 1 or 3 months after vaccination of 28 individuals and at 14 and 200 days after discharge of 15 convalescents. Notably, 89% of vaccines and 100% of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against one single mutation: E484Q. Besides, we found a significant decrease in neutralizing activity in convalescent patients and BBIBP-CorV vaccines for B.1.1.529. These findings demonstrate that inactivated-virus vaccination or convalescent sera showed reduced, but still significant, neutralization against the B.1.617.1 variant.