학술논문
Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
In order to validate a previously inferred function of the lateral prefrontal cortex (LPFC)-caudate nucleus (CdN) pathway in humans in inhibitory control and working memory, Oguchi et al used pathway-selective chemogenetic manipulation of neural activity in macaques. By suppressing pathway-specific neural activity and observing resultant behavioural changes, they provided evidence that the LPFC-CdN pathway does indeed play a role in inhibitory control.