학술논문
Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors
Document Type
article
Author
Laurel B. Darragh; Jacob Gadwa; Tiffany T. Pham; Benjamin Van Court; Brooke Neupert; Nicholas A. Olimpo; Khoa Nguyen; Diemmy Nguyen; Michael W. Knitz; Maureen Hoen; Sophia Corbo; Molishree Joshi; Yonghua Zhuang; Maria Amann; Xiao-Jing Wang; Steven Dow; Ross M. Kedl; Von Samedi; Mary-Keara Boss; Sana D. Karam
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increasing local and distant tumor growth in HNSCC preclinical models.