학술논문
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line
Document Type
article
Author
Artem Vorobyev; Yask Gupta; Tanya Sezin; Hiroshi Koga; Yannic C. Bartsch; Meriem Belheouane; Sven Künzel; Christian Sina; Paul Schilf; Heiko Körber-Ahrens; Foteini Beltsiou; Anna Lara Ernst; Stanislav Khil’chenko; Hassanin Al-Aasam; Rudolf A. Manz; Sandra Diehl; Moritz Steinhaus; Joanna Jascholt; Phillip Kouki; Wolf-Henning Boehncke; Tanya N. Mayadas; Detlef Zillikens; Christian D. Sadik; Hiroshi Nishi; Marc Ehlers; Steffen Möller; Katja Bieber; John F. Baines; Saleh M. Ibrahim; Ralf J. Ludwig
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.