학술논문
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Document Type
article
Author
Khaled Thabet; Anastasia Asimakopoulos; Maryam Shojaei; Manuel Romero-Gomez; Alessandra Mangia; William L. Irving; Thomas Berg; Gregory J. Dore; Henning Grønbæk; David Sheridan; Maria Lorena Abate; Elisabetta Bugianesi; Martin Weltman; Lindsay Mollison; Wendy Cheng; Stephen Riordan; Janett Fischer; Ulrich Spengler; Jacob Nattermann; Ahmed Wahid; Angela Rojas; Rose White; Mark W. Douglas; Duncan McLeod; Elizabeth Powell; Christopher Liddle; David van der Poorten; Jacob George; Mohammed Eslam; International Liver Disease Genetics Consortium
Source
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Chronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis development and progression.