학술논문
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
Document Type
article
Author
Jeroen Kneppers; Tesa M. Severson; Joseph C. Siefert; Pieter Schol; Stacey E. P. Joosten; Ivan Pak Lok Yu; Chia-Chi Flora Huang; Tunç Morova; Umut Berkay Altıntaş; Claudia Giambartolomei; Ji-Heui Seo; Sylvan C. Baca; Isa Carneiro; Eldon Emberly; Bogdan Pasaniuc; Carmen Jerónimo; Rui Henrique; Matthew L. Freedman; Lodewyk F. A. Wessels; Nathan A. Lack; Andries M. Bergman; Wilbert Zwart
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Epigenetic reprogramming of the androgen receptor (AR) has been identified as an important process driving prostate cancer (PCa) progression. Here, the authors analyze the role of AR chromatin binding heterogeneity in PCa clinical outcomes, metastasis and relapse.