학술논문
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation
Document Type
article
Author
Markus Meier; Monika Gupta; Serife Akgül; Matthew McDougall; Thomas Imhof; Denise Nikodemus; Raphael Reuten; Aniel Moya-Torres; Vu To; Fraser Ferens; Fabian Heide; Gay Pauline Padilla-Meier; Philipp Kukura; Wenming Huang; Birgit Gerisch; Matthias Mörgelin; Kate Poole; Adam Antebi; Manuel Koch; Jörg Stetefeld
Source
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.