학술논문
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility
Document Type
article
Author
Mitchell J. Machiela; Thomas G. P. Grünewald; Didier Surdez; Stephanie Reynaud; Olivier Mirabeau; Eric Karlins; Rebeca Alba Rubio; Sakina Zaidi; Sandrine Grossetete-Lalami; Stelly Ballet; Eve Lapouble; Valérie Laurence; Jean Michon; Gaelle Pierron; Heinrich Kovar; Nathalie Gaspar; Udo Kontny; Anna González-Neira; Piero Picci; Javier Alonso; Ana Patino-Garcia; Nadège Corradini; Perrine Marec Bérard; Neal D. Freedman; Nathaniel Rothman; Casey L. Dagnall; Laurie Burdett; Kristine Jones; Michelle Manning; Kathleen Wyatt; Weiyin Zhou; Meredith Yeager; David G. Cox; Robert N. Hoover; Javed Khan; Gregory T. Armstrong; Wendy M. Leisenring; Smita Bhatia; Leslie L. Robison; Andreas E. Kulozik; Jennifer Kriebel; Thomas Meitinger; Markus Metzler; Wolfgang Hartmann; Konstantin Strauch; Thomas Kirchner; Uta Dirksen; Lindsay M. Morton; Lisa Mirabello; Margaret A. Tucker; Franck Tirode; Stephen J. Chanock; Olivier Delattre
Source
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.