학술논문
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses
Document Type
article
Author
Weina Sun; Yonghong Liu; Fatima Amanat; Irene González-Domínguez; Stephen McCroskery; Stefan Slamanig; Lynda Coughlan; Victoria Rosado; Nicholas Lemus; Sonia Jangra; Raveen Rathnasinghe; Michael Schotsaert; Jose L. Martinez; Kaori Sano; Ignacio Mena; Bruce L. Innis; Ponthip Wirachwong; Duong Huu Thai; Ricardo Das Neves Oliveira; Rami Scharf; Richard Hjorth; Rama Raghunandan; Florian Krammer; Adolfo García-Sastre; Peter Palese
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Here the authors show that a Newcastle disease virus based COVID-19 vaccine expressing a stabilized spike protein induces protective immunity in small animal models and reduces replication of variants of concerns. This vaccine candidate can be produced by influenza virus vaccine manufactures around the world.