학술논문
Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer
Document Type
article
Author
Source
Cell Reports, Vol 43, Iss 1, Pp 113641- (2024)
Subject
Language
English
ISSN
2211-1247
Abstract
Summary: Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide association study to investigate the association between genetic variants and tumor mutation burden to interpret ICB response. We identified 16 variants (p