학술논문
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
Document Type
article
Author
Meixia Che; Aashi Chaturvedi; Sarah A. Munro; Samuel P. Pitzen; Alex Ling; Weijie Zhang; Josh Mentzer; Sheng-Yu Ku; Loredana Puca; Yanyun Zhu; Andries M. Bergman; Tesa M. Severson; Colleen Forster; Yuzhen Liu; Jacob Hildebrand; Mark Daniel; Ting-You Wang; Luke A. Selth; Theresa Hickey; Amina Zoubeidi; Martin Gleave; Rohan Bareja; Andrea Sboner; Wayne Tilley; Jason S. Carroll; Winston Tan; Manish Kohli; Rendong Yang; Andrew C. Hsieh; Paari Murugan; Wilbert Zwart; Himisha Beltran; R. Stephanie Huang; Scott M. Dehm
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
While many treatments for prostate cancer suppress the androgen receptor it becomes reactivated during disease progression. Here, the authors show that a KLF5 transcriptional programme is also activated during treatment and promotes migration and the appearance of a basal cell phenotype.