학술논문
Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk.
Document Type
article
Author
Sara Karami; Paul Brennan; Philip S Rosenberg; Marie Navratilova; Dana Mates; David Zaridze; Vladimir Janout; Helena Kollarova; Vladimir Bencko; Vsevolod Matveev; Neonila Szeszenia-Dabrowska; Ivana Holcatova; Meredith Yeager; Stephen Chanock; Idan Menashe; Nathaniel Rothman; Wong-Ho Chow; Paolo Boffetta; Lee E Moore
Source
PLoS ONE, Vol 4, Iss 9, p e7013 (2009)
Subject
Language
English
ISSN
1932-6203
Abstract
In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene. Therefore, analysis of genetic variation in VDR and other vitamin D pathway genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology. RCC cases (N = 777) and controls (N = 1,035) were genotyped to investigate the relationship between RCC risk and variation in eight target genes. Minimum-p-value permutation (Min-P) tests were used to identify genes associated with risk. A three single nucleotide polymorphism (SNP) sliding window was used to identify chromosomal regions with a False Discovery Rate of