학술논문
FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response and transcription-associated replication stress. These findings suggest a FANCD2-mediated coordination of nuclear and mitochondrial responses to stress.