학술논문
Microvascular Complications in Type 1 Diabetes: A Comparative Analysis of Patients Treated with Autologous Nonmyeloablative Hematopoietic Stem-Cell Transplantation and Conventional Medical Therapy
Document Type
article
Author
Jaquellyne G. Penaforte-Saboia; Renan M. Montenegro; Carlos E. Couri; Livia A. Batista; Ana Paula D. R. Montenegro; Virginia O. Fernandes; Hussain Akhtar; Carlos A. Negrato; Kelen Cristina Ribeiro Malmegrim; Daniela Aparecida Moraes; Juliana B. E. Dias; Belinda P. Simões; Marilia Brito Gomes; Maria Carolina Oliveira
Source
Frontiers in Endocrinology, Vol 8 (2017)
Subject
Language
English
ISSN
1664-2392
Abstract
ObjectiveTo explore the impact on microvascular complications, long-term preservation of residual B-cell function and glycemic control of patients with type 1 diabetes treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) compared with conventional medical therapy (CT).Research design and methodsCross-sectional data of patients treated with AHST were compared with patients who received conventional therapy from the Brazilian Type 1 Diabetes Study Group, the largest multicenter observational study in type 1 diabetes mellitus in Brazil. Both groups of patients had diabetes for 8 years on average. An assessment comparison was made on the presence of microvascular complications, residual function of B cell, A1c, and insulin dose of the patients.ResultsAfter a median of 8 years of diagnosis, none of the AHST-treated patients (n = 24) developed microvascular complications, while 21.5% (31/144) had at least one (p