학술논문
Genetic variants associated with platelet count are predictive of human disease and physiological markers
Document Type
article
Author
Evgenia Mikaelsdottir; Gudmar Thorleifsson; Lilja Stefansdottir; Gisli Halldorsson; Jon K. Sigurdsson; Sigrun H. Lund; Vinicius Tragante; Pall Melsted; Solvi Rognvaldsson; Kristjan Norland; Anna Helgadottir; Magnus K. Magnusson; Gunnar B. Ragnarsson; Sigurdur Y. Kristinsson; Sigrun Reykdal; Brynjar Vidarsson; Ingibjorg J. Gudmundsdottir; Isleifur Olafsson; Pall T. Onundarson; Olof Sigurdardottir; Emil L. Sigurdsson; Gerdur Grondal; Arni J. Geirsson; Gudmundur Geirsson; Julius Gudmundsson; Hilma Holm; Saedis Saevarsdottir; Ingileif Jonsdottir; Gudmundur Thorgeirsson; Daniel F. Gudbjartsson; Unnur Thorsteinsdottir; Thorunn Rafnar; Kari Stefansson
Source
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.